SAFE-Diff: Scale-Aware Attention and Feature-Dispersive Diffusion with Uncertainty Estimation for Contrast-Enhanced Breast MRI Synthesis

Synthesizing high fidelity contrast enhanced MRI is clinically valuable for safer and more efficient breast cancer screening, yet remains challenging due to complex lesion textures and heterogeneous enhancement patterns.

Universal CT Representations from Anatomy to Disease Phenotype through Agglomerative Pretraining

Computed tomography (CT) is a central to three-dimensional medical imaging, yet CT-based artificial intelligence remains fragmented across task-specific models for segmentation, classification, registration, and report analysis. Here we present FlexiCT, a family of CT foundation models trained by agglomerative continual pretraining on 266,227 CT volumes from 56 publicly available datasets, forming a large-scale public resource for CT representation learning. FlexiCT uses agglomerative pretraining across three stages: two-dimensional axial pretraining, three-dimensional anatomical pretraining and report-guided semantic alignment. This training strategy supports slice-level, volume-level and vision-language analysis. Across five downstream task families (segmentation, classification, registration, vision-language understanding and clinical retrieval), FlexiCT matches or exceeds prior task-specific approaches on multiple benchmarks. Its embeddings further organize CT scans along gradients associated with various tumor stages, suggesting that CT foundation models can capture imaging features relevant to disease phenotype characterization. Code is available at https://github.com/ricklisz/FlexiCT

MedMemoryBench: Benchmarking Agent Memory in Personalized Healthcare

The large-scale deployment of personalized healthcare agents demands memory mechanisms that are exceptionally precise, safe, and capable of long-term clinical tracking. However, existing benchmarks primarily focus on daily open-domain conversations, failing to capture the high-stakes complexity of real-world medical applications. Motivated by the stringent production requirements of an industry-leading health management agent serving tens of millions of active users, we introduce MedMemoryBench. We develop a human-agent collaborative pipeline to synthesize highly realistic, long-horizon medical trajectories based on clinically grounded, synthetic patient archetypes. This process yields a massive, expertly validated dataset comprising approximately 2,000 sessions and 16,000 interaction turns. Crucially, MedMemoryBench departs from traditional static evaluations by pioneering an "evaluate-while-constructing" streaming assessment protocol, which precisely mirrors dynamic memory accumulation in production environments. Furthermore, we formalize and systematically investigate the critical phenomenon of memory saturation, where sustained information influx actively degrades retrieval and reasoning robustness. Comprehensive benchmarking reveals severe bottlenecks in mainstream architectures, particularly concerning complex medical reasoning and noise resilience. By exposing these fundamental flaws, MedMemoryBench establishes a vital foundation for developing robust, production-ready medical agents.

FedVSSAM: Mitigating Flatness Incompatibility in Sharpness-Aware Federated Learning

Sharpness-aware minimization (SAM) is an effective method for improving the generalization of federated learning (FL) by steering local training toward flat minima. Under data heterogeneity, however, device-side SAM searches for locally flat basins that are incompatible with the flat region preferred by the global objective. We identify this structural failure mode as flatness incompatibility, which explains why improving local flatness alone may provide limited training and generalization improvement for the global model. We reveal that flatness incompatibility arises from data heterogeneity and the friendly adversary phenomenon, and is further amplified by local updates and partial device participation. To mitigate this issue, we propose Federated Learning with variance-suppressed sharpness-aware minimization (FedVSSAM), which constructs a variance-suppressed adjusted direction and uses it consistently in local flatness search, local descent, and global update. FedVSSAM anchors both perturbation and update directions to a more stable global direction, instead of correcting only an isolated local perturbation. We establish non-convex convergence guarantees of FedVSSAM and prove that the mean-square deviation between the adjusted direction and the global gradient is effectively controlled. Experiments demonstrate that FedVSSAM mitigates flatness incompatibility and outperforms the baselines across diverse FL settings.

RoboAlign-R1: Distilled Multimodal Reward Alignment for Robot Video World Models

Existing robot video world models are typically trained with low-level objectives such as reconstruction and perceptual similarity, which are poorly aligned with the capabilities that matter most for robot decision making, including instruction following, manipulation success, and physical plausibility. They also suffer from error accumulation in long-horizon autoregressive prediction. We present RoboAlign-R1, a framework that combines reward-aligned post-training with stabilized long-horizon inference for robot video world models. We construct RobotWorldBench, a benchmark of 10,000 annotated video-instruction pairs collected from four robot data sources, and train a multimodal teacher judge, RoboAlign-Judge, to provide fine-grained six-dimensional evaluation of generated videos. We then distill the teacher into a lightweight student reward model for efficient reinforcement-learning-based post-training. To reduce long-horizon rollout drift, we further introduce Sliding Window Re-encoding (SWR), a training-free inference strategy that periodically refreshes the generation context. Under our in-domain evaluation protocol, RoboAlign-R1 improves the aggregate six-dimension score by 10.1% over the strongest baseline, including gains of 7.5% on Manipulation Accuracy and 4.6% on Instruction Following; these ranking improvements are further supported by an external VLM-based cross-check and a blinded human study. Meanwhile, SWR improves long-horizon prediction quality with only about 1% additional latency, yielding a 2.8% gain in SSIM and a 9.8% reduction in LPIPS. Together, these results show that reward-aligned post-training and stabilized long-horizon decoding improve task consistency, physical realism, and long-horizon prediction quality in robot video world models.

LoGo-MR: Screening Breast MRI for Cancer Risk Prediction by Efficient Omni-Slice Modeling

Efficient and explainable breast cancer (BC) risk prediction is critical for large-scale population-based screening. Breast MRI provides functional information for personalized risk assessment. Yet effective modeling remains challenging as fully 3D CNNs capture volumetric context at high computational cost, whereas lightweight 2D CNNs fail to model inter-slice continuity. Importantly, breast MRI modeling for shor- and long-term BC risk stratification remains underexplored. In this study, we propose LoGo-MR, a 2.5D local-global structural modeling framework for five-year BC risk prediction. Aligned with clinical interpretation, our framework first employs neighbor-slice encoding to capture subtle local cues linked to short-term risk. It then integrates transformer-enhanced multiple-instance learning (MIL) to model distributed global patterns related to long-term risk and provide interpretable slice importance. We further apply this framework across axial, sagittal, and coronal planes as LoGo3-MR to capture complementary volumetric information. This multi-plane formulation enables voxel-level risk saliency mapping, which may assist radiologists in localizing risk-relevant regions during breast MRI interpretation. Evaluated on a large breast MRI screening cohort (~7.5K), our method outperforms 2D/3D baselines and existing SOTA MIL methods, achieving AUCs of 0.77-0.69 for 1- to 5-year prediction and improving C-index by ~6% over 3D CNNs. LoGo3-MR further improves overall performance with interpretable localization across three planes, and validation across seven backbones shows consistent gains. These results highlight the clinical potential of efficient MRI-based BC risk stratification for large-scale screening. Code will be released publicly.

Conditional Diffusion-Based Point Cloud Imaging for UAV Position and Attitude Sensing

This paper studies an unmanned aerial vehicle (UAV) position and attitude sensing problem, where a base station equipped with an antenna array transmits signals to a predetermined potential flight region of a flying UAV, and exploits the reflected echoes for wireless imaging. The UAV is represented by an electromagnetic point cloud in this region that contains its spatial information and electromagnetic properties (EPs), enabling the unified extraction of UAV position, attitude, and shape from the reconstructed point cloud. To accomplish this task, we develop a generative UAV sensing approach. The position and signal-to-noise ratio embedding are adopted to assist the UAV features extraction from the estimated sensing channel under the measurement noise and channel variations. Guided by the obtained features, a conditional diffusion model is utilized to generate the point cloud. The simulation results demonstrate that the reconstructed point clouds via the proposed approach present higher fidelity compared to the competing schemes, thereby enabling a more accurate capture of the UAV attitude and shape information, as well as a more precise position estimation.

DreamLite: A Lightweight On-Device Unified Model for Image Generation and Editing

Diffusion models have made significant progress in both text-to-image (T2I) generation and text-guided image editing. However, these models are typically built with billions of parameters, leading to high latency and increased deployment challenges. While on-device diffusion models improve efficiency, they largely focus on T2I generation and lack support for image editing. In this paper, we propose DreamLite, a compact unified on-device diffusion model (0.39B) that supports both T2I generation and text-guided image editing within a single network. DreamLite is built on a pruned mobile U-Net backbone and unifies conditioning through in-context spatial concatenation in the latent space. It concatenates images horizontally as input, using a (target | blank) configuration for generation tasks and (target | source) for editing tasks. To stabilize the training of this compact model, we introduce a task-progressive joint pretraining strategy that sequentially targets T2I, editing, and joint tasks. After high-quality SFT and reinforcement learning, DreamLite achieves GenEval (0.72) for image generation and ImgEdit (4.11) for image editing, outperforming existing on-device models and remaining competitive with several server-side models. By employing step distillation, we further reduce denoising processing to just 4 steps, enabling our DreamLite could generate or edit a 1024 x 1024 image in less than 1s on a Xiaomi 14 smartphone. To the best of our knowledge, DreamLite is the first unified on-device diffusion model that supports both image generation and image editing.

Taming the Instability: A Robust Second-Order Optimizer for Federated Learning over Non-IID Data

In this paper, we present Federated Robust Curvature Optimization (FedRCO), a novel second-order optimization framework designed to improve convergence speed and reduce communication cost in Federated Learning systems under statistical heterogeneity. Existing second-order optimization methods are often computationally expensive and numerically unstable in distributed settings. In contrast, FedRCO addresses these challenges by integrating an efficient approximate curvature optimizer with a provable stability mechanism. Specifically, FedRCO incorporates three key components: (1) a Gradient Anomaly Monitor that detects and mitigates exploding gradients in real-time, (2) a Fail-Safe Resilience protocol that resets optimization states upon numerical instability, and (3) a Curvature-Preserving Adaptive Aggregation strategy that safely integrates global knowledge without erasing the local curvature geometry. Theoretical analysis shows that FedRCO can effectively mitigate instability and prevent unbounded updates while preserving optimization efficiency. Extensive experiments show that FedRCO achieves superior robustness against diverse non-IID scenarios while achieving higher accuracy and faster convergence than both state-of-the-art first-order and second-order methods.

AnalogAgent: Self-Improving Analog Circuit Design Automation with LLM Agents

Recent advances in large language models (LLMs) suggest strong potential for automating analog circuit design. Yet most LLM-based approaches rely on a single-model loop of generation, diagnosis, and correction, which favors succinct summaries over domain-specific insight and suffers from context attrition that erases critical technical details. To address these limitations, we propose AnalogAgent, a training-free agentic framework that integrates an LLM-based multi-agent system (MAS) with self-evolving memory (SEM) for analog circuit design automation. AnalogAgent coordinates a Code Generator, Design Optimizer, and Knowledge Curator to distill execution feedback into an adaptive playbook in SEM and retrieve targeted guidance for subsequent generation, enabling cross-task transfer without additional expert feedback, databases, or libraries. Across established benchmarks, AnalogAgent achieves 92% Pass@1 with Gemini and 97.4% Pass@1 with GPT-5. Moreover, with compact models (e.g., Qwen-8B), it yields a +48.8% average Pass@1 gain across tasks and reaches 72.1% Pass@1 overall, indicating that AnalogAgent substantially strengthens open-weight models for high-quality analog circuit design automation.